DNA diagnostics based on mass spectrometry

US7198893B1 · kind B1 · utility

Assignee

• Sequenom, Inc. · US

Inventors

• Hubert Koster · Village of La Jolla, US
• Andreas Braun · San Diego, US
• Dirk Johannes Van Den Boom · Dreieich, DE
• Christian Jurinke · Village of La Jolla, US
• Andreas Ruppert · Siegsdorf, DE
• Franz Hillenkamp · Münster, DE
• Daniel P. Little · Ebensburg, US

Key dates

• Filing date: Oct 10, 2000
• Grant date: Apr 3, 2007
• Expiry date: Mar 27, 2021

Classification

• Technology area (CPC H): Electricity
• CPC primary: H01J49/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.