Reflective substrate and algorithms for 3D biochip
US7198901B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 16, 2003 |
| Grant date | Apr 3, 2007 |
| Priority date | — |
| Expiry date | Nov 30, 2024 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/168
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A reflective substrate is used to amplify the photon signal captured from overlying analyte domains containing photon emitters. The reflective substrate provides substantial desired signal amplification of the photon emissions from each domain via interference effects induced in the incident excitation and/or emission energies. A dielectric is interposed between the domains and the reflective surface, which has a thickness such that substantial destructive interference occurs with respect to emission photons or excitation photons or both at the attachment surface. When analyte domains have a three-dimensional structure such that a significant fraction of their volume extends at least ¼ wavelength above the attachment surface provided by the dielectric, substantial constructive signal amplification can take place of signals generated within the analyte domains. Destructive interference relating to emissions arising from the plane of attachment surface yields significant reduction in spurious background emissions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.