Binding domains between presenilins and their substrates as targets for drug screening
US7198903B2 · kind B2 · utility
0Cited by
2References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 15, 2003 |
| Grant date | Apr 3, 2007 |
| Priority date | — |
| Expiry date | Dec 27, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4711
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to the identification of the molecular binding domains between presenilins and its substrates such as amyloid precursor protein and telencephalin. These binding domains can be efficiently used in drug screening assays to screen for compounds capable of modulating the interaction between presenilins and type I transmembrane proteins. The invention further relates to compounds capable of modulating the interaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.