17α-fluorosteroids, pharmaceutical compositions containing 17α-fluorosteroids and a method of making them

US7199115B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ulrich Bothe · Berlin, DE
• Peter Droescher · Weimar, DE
• Walter Elger · Berlin, DE
• Gudrun Reddersen · Jena, DE
• Bernd Menzenbach · Jena, DE
• Hans-Udo Schweikert · Bonn, DE
• Alexander Hillisch · Solingen, DE
• Birgitt Schneider · Jena, DE

Key dates

• Filing date: Apr 13, 2005
• Grant date: Apr 3, 2007
• Expiry date: May 30, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J3/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New 17α-fluorosteroid compounds of formula (I) are disclosed:wherein R1 denotes H or methyl; R2 and R3 each denote H, Cl or methyl; and either a double bond or a single bond is present between C-6 and C-7 and also C-9 and C-10 of the steroid ring system respectively. These compounds have an activity profile with hybrid character so that they act as inhibitors for 5α-reductase and as high potency gestagens. Pharmaceutical compositions containing them are disclosed. They are suitable for treatment of conditions, which are caused by high levels of androgen in organs and tissues. These new compounds can be used in combination with other hormonal substances, such as estrogens, testosterone and other androgens, as contraceptives and for other applications.