Pyrazine compounds as transforming growth factor (TGF) compounds
US7199123B2 · kind B2 · utility
58Cited by
5References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 10, 2004 |
| Grant date | Apr 3, 2007 |
| Priority date | — |
| Expiry date | Dec 7, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel pyrazine compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.