Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors

US7199133B2 · kind B2 · utility

Assignee

• Merck Patentgesellschaft · DE

Inventors

• Dieter Dorsch · Ober-Ramstadt, DE
• Bertram Cezanne · Mörfelden, DE
• Christos Tsaklakidis · Weinheim, DE
• Werner Mederski · Zwingenberg, DE
• Johannes Gleitz · Darmstadt, DE
• Christopher Barnes · Bad Soden, DE

Key dates

• Filing date: Oct 10, 2002
• Grant date: Apr 3, 2007
• Expiry date: Jan 9, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds of formula (I), wherein D, W, X, Y, T and R1 have the meanings cited in claim 1, are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors