Patent · US Expired

Human extracellular matrix-1

US7199225B2 · kind B2 · utility

0Cited by

2References

7Claims

0Family size

Assignees

HUMAN GENOME SCIENCES, INC. · US
University of Antwerp · BE

Inventors

Jian Ni · Rockville, US
Ping Feng · Gaithersburg, US
Patrick J. Dillon · Carlsbad, US
Reiner Gentz · Silver Spring, US
Joseph Merregaert · Ekeren, BE
Patrick Smits · Herenthout, BE

Key dates

Filing date	May 12, 2003
Grant date	Apr 3, 2007
Priority date	—
Expiry date	Feb 1, 2024

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T436/143333
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.