Identification of kinase inhibitors
US7202033B2 · kind B2 · utility
61Cited by
2References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 20, 2003 |
| Grant date | Apr 10, 2007 |
| Priority date | — |
| Expiry date | Jun 9, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using a covalent tethering approach to identify inhibitors preferentially targeting the inactive conformation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.