Stabilized liquid preparation of the protease which activates blood coagulation factor VII, or of its proenzyme

US7202065B2 · kind B2 · utility

Assignee

• ZLB Behring AG · CH

Inventors

• Jürgen Römisch · Marburg, DE
• Annette Feussner · Marburg, DE
• Christian Kannemeier · Marburg, DE
• Hans-Arnold Stohr · Wetter, DE

Key dates

• Filing date: Jan 3, 2002
• Grant date: Apr 10, 2007
• Expiry date: Sep 2, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A stabilized liquid preparation of a protease which activates blood coagulation Factor VII or of its proenzyme is herein described. The preparation also contains one or more compounds selected from the group consisting of ornithine, diaminopimelic acid, agmatine, creatine, guanidinoacetic acid, acetylornithine, citrulline, arginoinosuccinic acid, tranexamic acid and epsilon-aminocaproic acid or their salts and has a pH of 2–8.