Indinavir derivatives useful in immunoassay
US7202092B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 12, 2004 |
| Grant date | Apr 10, 2007 |
| Priority date | — |
| Expiry date | Sep 17, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/94
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the indane ring hydroxyl group or the pyridine ring nitrogen of indinavir. Also disclosed is synthesis of a major metabolite of indinavir (M6) in a single step from indinavir using palladium catalyst and hydrogen gas. Indinavir M6 has been extended to synthesize various analogs of indinavir with suitable functional groups. These derivatives are useful in the development of indinavir immunogens, antibodies, and labeled conjugates in the development of indinavir immunoassays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.