Convenient stable non-hygroscopic crystalline solid forms of racemic and chiral LA-plus salts: process for their manufacture and uses
US7202270B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Jun 15, 2004 |
| Grant date | Apr 10, 2007 |
| Priority date | — |
| Expiry date | Aug 11, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D339/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the manufacture of new crystalline salts of N-[2-(dimethylamino)ethyl]-1,2-dithiolane-3-pentanamide (racemic and chiral forms) is described. Such salts are stable, crystalline and have very good solubility in water. The salts exhibit antioxidant properties. They inhibit collagenase and elastase enzymes. They have excellent anti acne activity in addition tyrosinase inhibition. They are, by themselves and in combination with other known agents, important cosmetic ingredients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.