Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US7202370B2 · kind B2 · utility
7Cited by
64References
19Claims
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Key dates
| Filing date | Oct 27, 2003 |
| Grant date | Apr 10, 2007 |
| Priority date | — |
| Expiry date | May 11, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D305/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.