Animal with the mass expression of human gene and test method by using the animal
US7202394B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 5, 2000 |
| Grant date | Apr 10, 2007 |
| Priority date | — |
| Expiry date | Dec 23, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0368
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application provides a human gene over-expressing animal, which is a non-human animal carrying a human hematopoietic prostaglandin D2 synthase gene in its somatic cell chromosome and expressing a large amount of human prostaglandin D2 synthase, wherein the animal is one obtained through ontogenesis of a totipotency cell of a non-human animal or offspring of the obtained animal, and the totipotency cell is introduced with said synthase gene. The present application also provides a method of using the transgenic animal for testing in vivo activity of a candidate for anti-allergy medicines, sleep-controlling substances and candidates for anti-obesity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.