Selected CGRP-antagonists process for preparing them and their use as pharmaceutical compositions

US7205294B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Philipp Lustenberger · Warthausen, DE
• Klaus Rudolf · Warthausen, DE
• Stephan Georg Mueller · Warthausen, DE
• Dirk Stenkamp · Biberach, DE
• Henri Doods · Warthausen, DE
• Kirsten Arndt · Biberach, DE
• Gerhard Schaenzle · Biberach, DE

Key dates

• Filing date: Mar 3, 2005
• Grant date: Apr 17, 2007
• Expiry date: Mar 3, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted piperidines of general formulawherein A, B, D, E, X, R1 and R2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.