Stabilized bioactive preparations and method of use

US7205343B2 · kind B2 · utility

Inventors

• Luis A. Dellamary · San Marcos, US
• Thomas E. Tarara · San Diego, US
• Alexey S. Kabalnov · Corvallis, US
• Jeffry Weers · San Diego, US
• Ernest G. Schutt · San Diego, US

Key dates

• Filing date: Dec 3, 2001
• Grant date: Apr 17, 2007
• Expiry date: Dec 3, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/926
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.