Proteins and methods for producing the proteins
US7205397B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 17, 1998 |
| Grant date | Apr 17, 2007 |
| Priority date | — |
| Expiry date | Jan 9, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P19/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis. The protein can be isolated and purified from the culture medium of fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity for the protein or a method for determining protein concentration using these antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.