Patent · US Expired

Process for the Kumada coupling reaction

US7205414B2 · kind B2 · utility

1Cited by

6References

23Claims

0Family size

Assignee

HONEYWELL INTERNATIONAL INC. · US

Inventors

Christian Werner · Hannover, DE
Frauke Platz · Lüdinghausen, DE
Andreas Kanschik-Conradsen · Garbsen, DE

Key dates

Filing date	Jan 12, 2005
Grant date	Apr 17, 2007
Priority date	—
Expiry date	Oct 17, 2025

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D333/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A method for the formation of 3-alkylthiophenes or 3-arylthiophenes from 3-halothiophenes. More particularly, improvements on the Kumada coupling reaction for the production of 3-alkylthiophenes or 3-arylthiophenes by reacting a 3-halothiophene with an alkylmagnesiumhalide or arylmagnesiumhalide Grignard reagent in the presence of a catalyst and a 2-methyl tetrahydrofuran solvent. The 2-methyl tetrahydrofuran solvent allows for higher concentrations of the Grignard reagent with minimal or no dithienyl side product generation, achieving higher product yields and at a lower cost than other known methods.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.