Methods for measuring therapy resistance
US7206699B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 18, 2001 |
| Grant date | Apr 17, 2007 |
| Priority date | — |
| Expiry date | Feb 16, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B50/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the development of resistance to one or more drugs is obtained from the generated genetic code, a genotype database is interrogated for previous samples with similar mutations relating to said one or more drugs, a phenotype for said sample is located in a phenotype database, the mean change in inhibition is determined based on all the examples located in said phenotype database, a distribution of sensitivities of one or more drugs suitable for treating a specific indication is determined.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.