Apparatus and method for down-regulating immune system mediators in blood
US7207964B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 17, 2003 |
| Grant date | Apr 24, 2007 |
| Priority date | — |
| Expiry date | Jan 13, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2230/207
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50–75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.