Method of synthesizing 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol
US7208484B2 · kind B2 · utility
3Cited by
18References
12Claims
0Family size
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Key dates
| Filing date | May 17, 2004 |
| Grant date | Apr 24, 2007 |
| Priority date | — |
| Expiry date | Dec 15, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of making 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol. The method includes the steps of condensing a bicyclic ketone with an allylic phosphine oxide to produce a protected 19-nor-pregnacalciferol analog, thereafter cleaving the protecting group to form 22-alcohol, converting the alcohol to an ester, reducing the ester to 17β-isopropyl-19-nor-vitamin D analog, and finally deprotecting the 17β-isopropyl derivative to form the desired compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.