Crystalline forms of halobetasol propionate

US7208485B2 · kind B2 · utility

Assignee

• Chemagis Ltd. · IL

Inventors

• Itai Adin · Beer Sheva, IL
• Yuri Futerman · Beer Sheva, IL
• Ori Lerman · Ramat Gan, IL
• Alexander Weisman · Kiryat Ekron, IL
• Chaim Ashkenazi · Gdera, IL
• Joseph Kaspi · Givatayim, IL

Key dates

• Filing date: Jan 13, 2003
• Grant date: Apr 24, 2007
• Expiry date: Feb 19, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J7/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a crystalline halobetasol propionate selected from the group consisting of halobetasol propionate having crystalline Form I characterized by power X-ray diffraction peak positions and intensities as set forth in Table 1 herein, halobetasol propionate having crystalline Form II characterized by power X-ray diffraction peak positions and intensities as set forth in Table 2 herein, halobetasol propionate having crystalline Form III characterized by power X-ray diffraction peak positions and intensities as set forth in Table 3 herein, halobetasol propionate having crystalline Form IV characterized by power X-ray diffraction peak positions and intensities as set forth in Table 4 herein, halobetasol propionate having crystalline Form V characterized by power X-ray diffraction peak positions and intensities as set forth in Table 5 herein, and halobetasol propionate having crystalline Form VI characterized by power X-ray diffraction peak positions and intensities as set forth in Table 6 herein.