Crystals of LuxP and complexes thereof
US7208612B2 · kind B2 · utility
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Key dates
| Filing date | Aug 22, 2002 |
| Grant date | Apr 24, 2007 |
| Priority date | — |
| Expiry date | Mar 21, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.