Process for oxidizing terpenes
US7211420B1 · kind B1 · utility
9Cited by
3References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 19, 1999 |
| Grant date | May 1, 2007 |
| Priority date | — |
| Expiry date | Nov 19, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for oxidizing a substrate which is an acyclic or cyclic terpene, or a cycloalkene; or a substituted derivative thereof, which process comprises oxidizing said compound with a mutant haem-containing enzyme, the mutant comprising the substitution of an amino acid in the active site by an amino acid with a less polar side-chain. The enzyme is typically P450cam or P450BM-3. Cells and libraries of cells in which the process can be carried out or which can be used to select advantageous mutant enzymes are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.