Synthetic human papilloma virus genes

US7211569B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Michael P. Neeper · Collegeville, US
• William L. McClements · Doylestown, US
• Kathrin Ute Jansen · Doylestown, US
• Loren D. Schultz · Harleysville, US
• Ling Chen · Shanghai, CN
• Xin Wang · Palo Alto, US

Key dates

• Filing date: Dec 4, 2003
• Grant date: May 1, 2007
• Expiry date: Dec 28, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.