Farnesyltransferase inhibitors

US7211595B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Akiyo K. Claiborne · Mundelein, US
• Stephen L. Gwaltney · San Diego, US
• Lisa A. Hasvold · Grayslake, US
• Qun Li · Beijing, CN
• Tongmei Li · Lake Bluff, US
• Nan-Horng Lin · Mundelein, US
• Robert A. Mantei · Franklin, US
• Todd W. Rockway · Gurnee, US
• Hing L. Sham · South San Francisco, US
• Gerard M. Sullivan · Round Lake Beach, US
• Yunsong Tong · Libertyville, US
• Gary T. Wang · Libertyville, US
• Le Wang · Xi'an, CN
• Xilu Wang · Grayslake, US
• Wei Wang · Grayslake, US

Key dates

• Filing date: Nov 30, 2001
• Grant date: May 1, 2007
• Expiry date: Apr 28, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.