Vitamin D derivatives with carbo-or heterocyclic substituents at C-25, a process for their production, intermediate products and their use for producing medicaments

US7211680B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Andreas Steinmeyer · Berlin, DE
• Gerald Kirsch · Berlin, DE
• Guenter Neef · Berlin, DE
• Katiea Schwarz · Berlin, DE
• Ruth Thieroff-Ekerdt · Concord, US
• Herbert Wiesinger · Berlin, DE
• Martin Haberey · Berlin, DE
• Marianne Fahnrich · Berlin, DE

Key dates

• Filing date: Sep 10, 2003
• Grant date: May 1, 2007
• Expiry date: Aug 16, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula I,wherein Y1, Y2, R1–R6, Q and Z are as defined herein, are vitamin D derivatives. These compounds are useful for, e.g., the treatment hyperprolifierative diseases of the skin, tumor diseases and precancerous stages, auto-immune diseases, rejection reactions in the case of autologous, allogenic or xenogenic transplants, AIDS, atopic skin conditions, secondary hyperparathyroidism, renal osteodystrophia, senile and postmenopausal osteoporosis, diabetes mellitus type II, degenerative diseases of the peripheral and central nervous system, hypercalcemias, granulomatous diseases, paraneoplastic hypercalcemias, hypercalcemias in hyperparathyroidism, hirsutism, ateriosclerosis, and/or inflammatory diseases.