Methods of inhibiting TNFα in patients with neoplastic disease

US7214376B2 · kind B2 · utility

Assignees

• NEW YORK UNIVERSITY · US
• Centocor, Inc. · US

Inventors

• Junming Le · New York, US
• Jan Vilcek · New York, US
• Peter Daddona · Menlo Park, US
• John Ghrayeb · Towanda, US
• David Knight · Berwyn, US
• Scott Siegel · Westborough, US

Key dates

• Filing date: Dec 7, 2001
• Grant date: May 8, 2007
• Expiry date: Jan 3, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.