E. coli O157:H7 C1-INH-binding protein and methods of use
US7214479B2 · kind B2 · utility
1Cited by
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4Claims
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Key dates
| Filing date | Feb 25, 2004 |
| Grant date | May 8, 2007 |
| Priority date | — |
| Expiry date | Mar 14, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosing enterohemorrhagic E. coli infection, identifying potential inhibitors of its activity, and reducing viscosity of material containing glycosylated polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.