Method for the preparation of fluticasone and related 17β-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
US7214807B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | May 18, 2004 |
| Grant date | May 8, 2007 |
| Priority date | — |
| Expiry date | May 18, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J31/003
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.