Method for the production of 4-(17α-substituted-3-oxoestra-4,9-dien-11β-yl)benzaldehyde-(1E)-oximes

US7214808B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerd Schubert · Jena, DE
• Sven Ring · Jena, DE
• Bernd Erhart · Kahla, DE

Key dates

• Filing date: Nov 9, 2001
• Grant date: May 8, 2007
• Expiry date: Jun 10, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method for the production of 4-(17α substituted 3-oxoestra-4,9-dien-11β-yl)benzaldehyd-(1E or 1Z)-oximes of general formula (I), where R1═H, C1-6 alkyl or a CnF2n+1 group; R2═C1-4 alkyl, X=E- or Z-OH; and Y═O—C1-6 alkyl, S—C1-6 alkyl or O—CH2CnF2n+1, where n=1, 2 or 3, which produces the target compounds of formula (I) with high yield and selectivity.