3,7-Diazabicyclo [3.3.1] formulations as anti-arrhythmic compounds

US7217708B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Neil Barnwell · Coalville, GB
• Annika Bjore · Stenungsund, SE
• Lal Cheema · Coalville, GB
• David Cladingboel · Mountsorrel, GB
• Adam Herring · Coalville, GB
• Karin Lövqvist · Mölndal, SE

Key dates

• Filing date: Apr 12, 2002
• Grant date: May 15, 2007
• Expiry date: Jun 16, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl) -9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tert-butyl 2 -{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate; tert-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tert-butyl 2-{7-[2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arhythmias.