Nucleic acids encoding factor X analogues having a modified protease cleavage site

US7220569B2 · kind B2 · utility

Assignee

• Baxter Aktiengesellschaft · AT

Inventors

• Michele Himmelspach · Port, CH
• Uwe Schlokat · Orth an der Donau, AT
• Friedrich Dorner · Wien, AT
• Andreas Fisch · Basel, CH
• Johann Eibl · Wien, AT

Key dates

• Filing date: Apr 4, 2003
• Grant date: May 22, 2007
• Expiry date: Jul 4, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acids encoding factor X analogues are provided that have a modification in the region of the natural Factor Xa activation cleavage site. The modification results in a processing site for a protease not naturally cleaving in this region of the Factor X sequence.