Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them

US7220750B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Frank Himmelsbach · Mittelbiberach, DE
• Elke Langkopf · Biberach an der Riß, DE
• Thomas Metz · Kennewick, US
• Flavio Solca · Wien, AT
• Birgit Jung · Laupheim, DE
• Anke Baum · Alland, AT

Key dates

• Filing date: Dec 10, 2001
• Grant date: May 22, 2007
• Expiry date: Oct 2, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to bicyclic heterocycles of general formulawhereinRa to Rc, A to E and X are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and airways, and the preparation thereof.