Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier
US7220833B2 · kind B2 · utility
9Cited by
4References
33Claims
0Family size
Inventors
Key dates
| Filing date | Dec 2, 2003 |
| Grant date | May 22, 2007 |
| Priority date | — |
| Expiry date | Dec 2, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/906
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particles comprised of three lipid elements: phosphatidyl choline, fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions, methods and kits comprising artificial LDL particles for targeting drugs to and across the BBB for the prevention and treatment of brain diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.