Residual solvent extraction method and microparticles produced thereby
US7223440B2 · kind B2 · utility
20Cited by
38References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 21, 2005 |
| Grant date | May 29, 2007 |
| Priority date | — |
| Expiry date | Dec 21, 2025 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/0877
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.