T1R3 receptor binding assays for identification of taste modulatory compounds
US7223551B2 · kind B2 · utility
59Cited by
1References
37Claims
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Key dates
| Filing date | Dec 4, 2003 |
| Grant date | May 29, 2007 |
| Priority date | — |
| Expiry date | May 28, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Binding assays for identifying ligands that modulate human T1R3 polypeptide-associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R3 polypeptide or the modulation of the specific binding of another compound that specifically binds human T1R3 polypeptide. The binding assays may include the use of detectable labels, e.g., radionuclides, enzymes, fluorophores, and the like. Compounds identified in these binding assays have potential application as T1R3 taste modulators and therefore potentially are useful additives in compositions for human or animal consumption.
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