Targeted proteolysis by recruitment to ubiquitin protein ligases
US7223556B1 · kind B1 · utility
16Cited by
1References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 8, 1999 |
| Grant date | May 29, 2007 |
| Priority date | — |
| Expiry date | Oct 8, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/20022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and reagents for inhibiting the ubiquitination and proteolysis of cellular proteins which are recognized by a ubiquitin protein ligase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.