Photochemical internalization for delivery of molecules into the cytosol

US7223600B2 · kind B2 · utility

Assignee

• The Norwegian Radium Hospital Research Foundation · NO

Inventors

• Kristian Berg · Heggedal, NO
• Lina Prasmickaite · Oslo, NO
• Anders Høgset · Oslo, NO
• Pal Kristian Selbo · Oslo, NO

Key dates

• Filing date: Nov 29, 2001
• Grant date: May 29, 2007
• Expiry date: Apr 28, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/5156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosentistising agent, the cell is irradiated with light of a wavelength effective to activate the photosentisitising agent and, substantially at the same time or after the irradiation, the cell is contacted with the molecule to be introduced, particularly for use in cancer treatment, gene therapy and vaccination.