Crystallographic structure of the androgen receptor ligand binding domain

US7225083B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Roberto Weinmann · Princeton, US
• Howard M. Einspahr · Lawrenceville, US
• Stanley Krystek · Ringoes, US
• John S. Sack · Lawrenceville, US
• Mark E. Salvati · Lawrenceville, US
• John S. Tokarski · Princeton, US
• Ricardo Attar · Lawrenceville, US
• Chihuei Wang · Plainsboro, US

Key dates

• Filing date: Jun 28, 2004
• Grant date: May 29, 2007
• Expiry date: Jun 28, 2024

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/723
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The first crystal structure of the androgen receptor ligand binding domain has been determined to 2.0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonists and selective androgen receptors modulators (SARMs) of the androgen receptor.