Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis

US7226578B2 · kind B2 · utility

Assignee

• Shering Corporation · DE

Inventors

• Johannes Platzek · Berlin, DE
• Ulrich Niedballa · Berlin, DE
• Bernd Raduchel · Berlin, DE
• Wolfgang Schlecker · Berlin, DE
• Hanns-Joachim Weinmann · Berlin, DE
• Thomas Frenzel · Berlin, DE
• Bernd Misselwitz · Berlin, DE
• Wolfgang Ebert · Krefeld, DE

Key dates

• Filing date: Oct 5, 2004
• Grant date: Jun 5, 2007
• Expiry date: Feb 20, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D257/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.