Expandable foam-like biomaterials and methods
US7226615B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 7, 2001 |
| Grant date | Jun 5, 2007 |
| Priority date | — |
| Expiry date | Sep 29, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/22
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.