In vitro and in vivo anti-inflammatory effects of a sesquiterpene lactone extract from chicory (Cichorium intybus L.)
US7226623B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 31, 2005 |
| Grant date | Jun 5, 2007 |
| Priority date | — |
| Expiry date | Oct 31, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P19/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of preparing a chicory extract enriched with sesquiterpene lactones is provided. The method includes performing an initial extraction chicory in a polar solvent, such as methanol or ethanol, at ambient temperature to form an alcoholic extract. The alcoholic extract is subsequently defatted with a non-polar solvent, preferably hexane or n-heptane. A second extraction of the defatted alcoholic extract is performed with a solvent which is more polar than the solvent used in the defatting process and less polar than the solvent used in the initial extraction, for example, it can be chosen from the group consisting of ethyl acetate, n-butanol, isopropanol, n-propanol, dichloromethane, acetonitrile, and mixtures thereof; resulting in a sesquiterpene lactones enriched extract, preferably containing at least 60% sesquiterpene lactones.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.