Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
US7226785B2 · kind B2 · utility
118Cited by
8References
45Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 27, 2002 |
| Grant date | Jun 5, 2007 |
| Priority date | — |
| Expiry date | Jan 8, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/346
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.