Phenylalanine derivatives

US7226991B1 · kind B1 · utility

Assignees

• THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · US
• Georgetown University · US

Inventors

• Terrence R. Burke, Jr. · Kirkwood, US
• Yang Gao · Hangzhou City, CN
• Zhu-jun Yao · Shanghai, CN
• Dajun Yang · Suzhou, CN

Key dates

• Filing date: Mar 23, 2000
• Grant date: Jun 5, 2007
• Expiry date: Mar 23, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are phenylalanine derivative compounds of the following formulaW—Y—(AA)n—Zwherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described herein. The compounds can be used to inhibit SH2 binding with phosphoproteins, and to inhibit proliferation of tumor cells.