Human antibodies that bind human 17-A1/EpCAM tumor antigen

US7227002B1 · kind B1 · utility

Assignee

• Micromet AG · DE

Inventors

• Peter Kufer · Munich, DE
• Tobias Raum · Munich, DE

Key dates

• Filing date: Apr 14, 1998
• Grant date: Jun 5, 2007
• Expiry date: Apr 14, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides an anti-human antibody or fragment thereof that is low or not immunogenic in humans. In particular, the antibodies or fragments are directed to human tumor antigens, preferably to the human tumor antigen 17-1A, also known as EpCAM, EGP or GA 733-2. Also provided are pharmaceutical compositions comprising the aforementioned antibodies or fragments thereto.