Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
US7227028B2 · kind B2 · utility
43Cited by
5References
84Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 30, 2004 |
| Grant date | Jun 5, 2007 |
| Priority date | — |
| Expiry date | Mar 30, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/416
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.