Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles
US7229605B2 · kind B2 · utility
4Cited by
16References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 13, 2004 |
| Grant date | Jun 12, 2007 |
| Priority date | — |
| Expiry date | Sep 16, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/33
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.