Patent · US Expired

Detection of apoptotic products

US7229772B1 · kind B1 · utility

2Cited by

3References

6Claims

0Family size

Assignee

Roche Diagnostics GMBH · DE

Inventors

Stefan HOLDENRIEDER · Munich, DE
Martin Busch · Grafing, DE
Heinz Bodenmueller · Tutzing, DE
Georg Fertig · Penzberg, DE
Andreas Schalhorn · Planegg, DE
Petra Stieber · Gauting, DE

Key dates

Filing date	Mar 18, 1999
Grant date	Jun 12, 2007
Priority date	—
Expiry date	Mar 18, 2019

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/52
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention concerns a method for the determination of apoptotic products in samples taken from patients in which apoptosis is induced as a result of disease or therapy, which is characterized in that the concentration of the apoptotic products in samples taken from patients is correlated with the effectiveness of the therapy and thus serves as a follow-up for the therapy. The serum samples are taken at various times and determined. The present invention in particular concerns a method in which the concentration of nucleosomes is determined in serum samples of tumour patients in order to assess the effectiveness of tumour therapy. Furthermore the present invention also concerns the use of a method according to the invention to determine the effectiveness of therapy in tumour patients who are subjected to a radiotherapy or chemotherapy treatment as well as in patients after an acute ischaemic event or after hypothermia treatment.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.