pH-sensitive polymeric micelles for drug delivery
US7229973B2 · kind B2 · utility
9Cited by
1References
46Claims
0Family size
Inventors
Key dates
| Filing date | May 19, 2003 |
| Grant date | Jun 12, 2007 |
| Priority date | — |
| Expiry date | Dec 7, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F8/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of making poly(L-histidine), synthetic intermediates, and block copolymers are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.