Patent · US Expired

Process for preparing water soluble phosphonooxymethyl derivatives of alcohol and phenol

US7229978B2 · kind B2 · utility

0Cited by
2References
26Claims
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Assignee

Inventors

Key dates

Filing dateDec 20, 2002
Grant dateJun 12, 2007
Priority date—
Expiry dateDec 20, 2022

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07F9/6561
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl derivatives comprises the steps of Formula (i) and Formula (ii); R—OH represents an alcohol- or phenol-containing drug, n represents an integer of 1 or 2, R1 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation, and R2 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.